![]() The iodine functional group in the products promised further modification of the core structure through well-known palladium-catalyzed coupling reactions. Our group designed a facile iodine monochloride-induced intramolecular cyclization of 1-(-2-yl)-alkynones, leading to 6-iododibenzocyclohepten-5-ones in high chemical yields. These reactions provide a facile approach toward the synthesis of a variety of functionally substituted heterocyclic and carbocyclic compounds, by the ready modification of the halide functionality, and have therefore attracted a significant amount of attention from synthetic chemists. Iodine-induced intramolecular electrophilic cyclization. Halogen-induced electrophilic cyclization reactions have emerged as an indispensable method for the synthesis of cyclic compounds, as they occur under relatively mild conditions. We then employed the reductive ring-opening mechanism in two iron-catalyzed cascade reactions, and successfully developed iron-mediated cascade syntheses of furans and pyrroles. ![]() An in-house aged N-methyl-2-pyrrolidone played the role as both a solvent and a hydrogen donor. The reaction took place via a transfer hydrogenation mechanism. We recently developed an iron-catalyzed reductive ring-opening of isoxazoles and isoxazolines. Iron-catalyzed transfer hydrogenation has attracted growing interest among chemists for its operational simplicity and economic nature. In addition, iron catalysts display various unique chemical reactivities different from the noble transition metals, which merits further attention. Iron-catalyzed reductive ring-opening of isoxazoles. As the second most abundant metal element in the earth’s crust, the environmentally friendly and low cost properties of iron make it a very attractive catalyst. The group is committed to designing and preparing new ligands with axial or facial chirality for efficient and highly stereoselective transition metal catalysis. The late transition metal catalyzed asymmetric synthesis is another major research topic of the Chen group. The group is particularly interested in palladium, gold, and iron catalyzed cascade reactions. The development of new chemical reactions mediated by transition metals is currently one of the main goals of Chen Group. Chen’s research interest includes transition metal catalysis, asymmetric synthesis and catalysis, and heterocyclic chemistry. degree at the University of Toronto with Professor Andrei Yudin and postdoctoral work at the Iowa State University with Professor Richard Larock. Yu Chen started his independent research career at Queens College - CUNY in August 2009 after finishing his Ph.D.
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